Drinking lots of fluids, resting, and taking acetaminophen might help. In addition to managing public health resources, accurate forecasting of the next epidemic foci is crucial for executing the evaluation of ZIKV vaccines and therapeutics in clinical trials.
Zika virus (ZIKV) is rapidly spreading across the America and its devastating outcomes for pregnant women and infants have driven this previously ignored. Open AccessArticle The Application and Interpretation of IgG Avidity and IgA ELISA Tests to Characterize Zika Virus Infections.
Animal models that recapitulate this neurologic disease in humans are required to test appropriate countermeasures, such as vaccines, antiviral molecules, or monoclonal antibodies. Duration of shedding in female genital secretions and in breast milk are also unknown, but these have implications for controlling epidemic spread.
Development of effective countermeasures, such as therapeutics and an effective vaccine, are also research priorities. A ZIKV therapeutic might also be useful for the treatment of infants born to ZIKV-infected mothers to lower their viral loads, prevent further damage to their central nervous system, and improve their clinical and developmental outcomes.
If a valid surrogate endpoint could be used in efficacy trials eg, prevention or reduction of viremiathe size of trials could be drastically reduced making them more feasible and less costly.
Serosurveillance studies in humans suggest that Zika virus is widespread throughout Africa, Asia, zika virus research paper Oceania Technical Appendix Table 1.
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- Vector control through pesticides or larvicides is also standard public health practice in limiting mosquito-borne diseases.
- Editorial: Zika Virus Research
- Zika Virus: MedlinePlus
Teratogenic effects of the Zika virus and the role of the placenta. Supplement sponsorship.
A collection of articles and other resources on the Zika virus outbreak, including .. As researchers investigate whether and by what mechanisms Zika virus. Scientific Reportsvolume 8, Article number: () | Download . Table 1 Non-human primates positive for Zika virus, by RT-qPCR.
This article was written by the National Institutes of Health employees in the course of their usual duties without additional funding support. Available from: The latest emerging and devastating threat was Zika virus, an arbovirus that provoked more thanautochthonous suspected disease cases in the Americas between and 2.
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A more detailed understanding of the physiology of vector olfaction might help identify new targets for the development of novel strategies to alter the mosquito olfactory sense and their biting behavior. Severe acute respiratory syndromeavian influenza in humansA H1N1 pandemic influenzaMiddle East respiratory syndrome coronavirus MERS-CoV onwardand Ebola virus disease — are some of the most important examples 1.
Updated Cell Press Statement on Publication of Zika Virus Research We are committed to handling Zika papers with the same thoughtful and timely approach . For close to 70 years, Zika virus has been considered to be low to moderate in risk to human health and the amount of research performed has reflected this.
Use insect repellent Wear clothes that cover your arms, legs, and feet Stay in places that have air conditioning or that use window and door screens Centers for Disease Control and Prevention Start Here.
As a sexually transmitted infection, the rate of ZIKV spread is thus likely to be influenced by the demographic structure and sexual mixing within a population [ 14 ], adding additional complexity to constructing models that accurately predict the next ZIKV epidemic.
The local transmission of Zika virus has been reported in more than 50 the scientific community by publishing research articles on the Zika virus and its. World Health Organization All rights reserved. Publications of the World Health Organization are available on the WHO website (thefireworkshoplist.com) or can be.
Research investments are always made with hopes for long-term benefits. In contrast, it will be important to understand whether exposure to ZIKV will change the course of disease to subsequent flavivirus infections such as dengue.
Editorial: Zika Virus Research
Notes Disclaimer. Vector control through pesticides or larvicides is also standard public health practice in limiting mosquito-borne diseases. J Neuroimmunol The potential role of pre-existing immunity to flaviviruses in ZIKV pathogenesis is another area of research that needs to be further developed to explore possible links between congenital Zika syndrome CZS and neurological disease severity and existing immunity to flaviviruses.
Editorial: Zika Virus Research . research papers about control strategies, encompassing virological, entomological, and epidemiological data. This article has been cited by other articles in PMC. Serosurveillance studies in humans suggest that Zika virus is widespread throughout Africa, Asia, and.
Historically, symptomatic Zika virus infections were limited to sporadic cases or small clusters of patients Technical Appendix Table 2. Observational cohorts comprised of exposed and unexposed infants in regions where there is ZIKV transmission that incorporate neurologic testing, developmental milestones, and cognitive outcomes through school age will further our understanding in this area.
Zika Virus - Article Selections - Elsevier
The time necessary to complete a vaccine trial requires brisk enrollment at sites with consistently high incidence. Natural history studies in endemic countries and studies in well characterized animal models can also advance our understanding of ZIKV immunological correlates of protection.
There are 3 factors that contributed to the rapid progress in ZIKV research: These questions highlight the need for research to optimize surveillance, patient management, and public health intervention in the current Zika virus epidemic. References 1.
Symptoms are usually mild, and start 2 to 7 days after being bitten by an infected mosquito. The causal link between ZIKV exposure and abnormal brain development became established early in the —16 Brazil epidemic through case-control studies of pregnant women and further bolstered by thesis usability testing from studies in animal models [ 12 ].
The Centers for Disease Control and Prevention recommends that pregnant women do not travel to areas where there is a Zika virus outbreak. In the framework of this global response and multistrategic approach, the purpose of this research topic was to provide a platform for the publication of updated information medizinische dissertation material und methoden high-quality research papers about control strategies, encompassing virological, entomological, and epidemiological data, in order to reach the triad of protagonists of transmission cycles virus, mosquitoes, and humans.
Finally, we will need to better understand the competence of different mosquito vectors for what is a great college essay ZIKV to target the development and implementation of vector-control strategies to the most important mosquito species.
ZIKA VIRUS INFECTION: NATURAL HISTORY AND MECHANISMS OF PATHOGENESIS
Ultimately, if such strategies prove safe and efficacious, pre- and postexposure prophylaxis for ZIKV-exposed women and male sex partners may limit the risk and devastation of CZS. Furthermore, Giri et al.
- These questions highlight the need for research to optimize surveillance, patient management, and public health intervention in the current Zika virus epidemic.
- Therefore, it is important to continue developing immune-competent animal models that recapitulate ZIKV pathogenesis and allow for the evaluation of interventions to prevent CZS [ 1617 ].
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Zika Transmission in South East Asia. Wider approach has been given by Shankar et al. West Nile virus, Chikungunya virus, and yellow fever virus epidemics have all demonstrated sporadic and unpredictable patterns of spread [ 8—13 ].
Short discussions by way of articles commentaries could not be missed in the topic.
Microbes and Infection
Previously limited to sporadic cases in Africa and Asia, the emergence of Zika virus in Brazil in heralded rapid spread throughout the Americas. One in five people do get symptoms, which can include a fever, rash, joint pain, and conjunctivitis pinkeye. Finally, some of the most relevant sources of knowledge of the Zika Virus research cover letter for banks customer service reside in several excellent reviews.
It came into the public consciousness—seemingly out of nowhere—spreading rapidly and causing a new disease congenital ZIKV syndrome. Additional research will be needed to convert these diagnostic platforms to rapid, point-of-care testing that can be applied clinically.
Zika Virus and Future Research Directions | The Journal of Infectious Diseases | Oxford Academic
Advanced Search Abstract There was a dramatic upsurge in research activity after the recognition of Zika virus ZIKV transmission in South America in and its causal relationship to devastating anomalies in newborn infants. Improved mfa creative writing wyoming diagnostics that are sensitive and specific for ZIKV are also urgently needed to be able to diagnose recent and past ZIKV infections and differentiate them from other arboviral infections with similar clinical manifestations especially dengue and CHIKV.
This information will better inform vaccine developers and public health authorities on the potential risks of introducing Zika vaccine in flavivirus-endemic areas. Some of the most pressing scientific gaps that need to be addressed to advance the field are summarized below.
Zika Virus Research | Frontiers Research Topic Nat Immunol 19 1: